Positive regulation of rRNA processing

Across TCGA patient cohorts, RNA activity of the Positive regulation of rRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDNF, CASP12, and SEPTIN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of rRNA processing activity versus NDNF in LUAD (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NDNF →	-1.057	-0.772	.002	<.001	3	6
CCRCC	CASP12 →	-0.520	-0.318	.001	.005	3	6
HNSC	SEPTIN4 →	-0.456	-0.164	.007	.008	3	5
CCRCC	EMCN →	-0.975	-0.461	.001	<.001	3	5
LSCC	ADAMTS9-AS2 →	-0.334	-0.252	.008	.007	2	6
BRCA	IRAG1 →	-0.820	-0.291	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000234 vs NDNF — LUAD

Explore this scatter interactively →