Regulation of rRNA processing

Across TCGA patient cohorts, RNA activity of the Regulation of rRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIF2A, CHD1_S1677, and AKR1C3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of rRNA processing activity versus KIF2A in CCRCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KIF2A →	+0.438	+0.039	.001	<.001	3	5
LUAD	CHD1_S1677 →	+0.392	+0.051	.002	<.001	3	5
LSCC	AKR1C3 →	+0.751	+0.026	.007	.004	3	4
BRCA	IFT74 →	+0.254	+0.020	.007	.003	3	4
BRCA	MORC2 →	-0.336	-0.030	<.001	<.001	3	4
LSCC	TNPO1 →	+0.215	+0.053	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000232 vs KIF2A — CCRCC

Explore this scatter interactively →