Positive regulation of anoikis

Across TCGA patient cohorts, RNA activity of the Positive regulation of anoikis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_S619, CMSS1, and DCAF13, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of anoikis activity versus NCL_S619 in PDAC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NCL_S619 →	+0.397	+0.054	.003	.001	3	7
LSCC	CMSS1 →	+0.528	+0.101	.001	<.001	3	7
LSCC	DCAF13 →	+0.349	+0.093	<.001	<.001	3	7
LSCC	DDX42 →	+0.209	+0.089	<.001	<.001	3	7
LSCC	RFC4 →	+0.373	+0.078	<.001	<.001	3	6
LSCC	COIL →	+0.348	+0.076	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000210 vs NCL_S619 — PDAC

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