Regulation of anoikis

Across TCGA patient cohorts, RNA activity of the Regulation of anoikis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAC9, HAAO, and RPL5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of anoikis activity versus PLAC9 in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLAC9 →	+1.166	+0.102	<.001	<.001	3	8
HNSC	HAAO →	+0.568	+0.080	<.001	<.001	3	8
BRCA	RPL5 →	-0.243	-0.056	<.001	<.001	3	7
OV	SEPTIN4 →	+0.418	+0.039	.001	<.001	3	7
BRCA	VDAC2_S115 →	-0.691	-0.061	<.001	<.001	3	7
OV	CNRIP1 →	+0.599	+0.053	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000209 vs PLAC9 — UCEC

Explore this scatter interactively →