Regulation of anoikis

Across TCGA patient cohorts, RNA activity of the Regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCH2, KCNQ5, and MIR4282, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of anoikis activity versus PLCH2 in GBM (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCH2 →	-0.879	-0.271	<.001	.001	3	5
HNSC	KCNQ5 →	+0.830	+0.153	.001	.001	3	3
HNSC	MIR4282 →	+1.133	+0.130	.001	.001	3	3
BRCA	SNCG →	-1.485	-0.217	<.001	.001	3	3
GBM	ZSCAN5A →	+0.422	+0.302	<.001	<.001	3	3
GBM	PVT1 →	+0.632	+0.286	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000209 vs PLCH2 — GBM

Explore this scatter interactively →