Positive regulation of fatty acid transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of fatty acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF19, UBA2, and PARP4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid transport activity versus PRPF19 in GBM (Pearson r = -0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRPF19 →	-0.206	-0.057	<.001	<.001	3	7
GBM	UBA2 →	-0.286	-0.062	.001	.001	3	6
GBM	PARP4 →	+0.598	+0.096	<.001	<.001	3	6
LSCC	SF3B3 →	-0.251	-0.067	<.001	<.001	3	6
GBM	SSRP1 →	-0.421	-0.074	<.001	<.001	3	6
GBM	SUPT16H →	-0.379	-0.068	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000193 vs PRPF19 — GBM

Explore this scatter interactively →