Negative regulation of fatty acid transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of fatty acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFC, TDG, and PRR5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid transport activity versus VEGFC in LUNG_NSCLC_LUSC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	VEGFC →	+3.392	+0.432	.005	.008	3	4
SOFT_TISSUE	TDG →	-1.002	-1.314	<.001	<.001	3	4
SOFT_TISSUE	PRR5 →	-3.332	-1.888	<.001	<.001	3	4
SOFT_TISSUE	PSORS1C1 →	+1.234	+1.363	.005	.001	3	4
SOFT_TISSUE	SETDB1 →	-0.930	-1.349	<.001	<.001	3	4
SOFT_TISSUE	COQ8A →	-0.744	-1.188	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000192 vs VEGFC — LUNG_NSCLC_LUSC

Explore this scatter interactively →