Negative regulation of neural precursor cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of neural precursor cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCD3, KATNB1, and ZMYND8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMARCD3 grouped by Negative regulation of neural precursor cell proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMARCD3 →	-1.304	-1.191	.003	<.001	3	4
KIDNEY	KATNB1 →	+0.941	+1.246	<.001	<.001	3	4
BLOOD_Leukemia	ZMYND8 →	+0.893	+1.230	.005	<.001	3	4
BLOOD_Leukemia	TAGLN →	-0.574	-0.938	.009	.006	3	4
LIVER	MERTK →	+1.854	+1.382	<.001	.003	3	4
OVARY	GCAT →	+0.854	+1.123	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMARCD3 by Negative regulation of neural precursor cell proliferation activity — BREAST

Explore this box plot interactively →