Regulation of branching morphogenesis of a nerve

Across TCGA patient cohorts, RNA activity of the Regulation of branching morphogenesis of a nerve pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K13, HTRA3, and CFD, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of branching morphogenesis of a nerve activity versus MAP3K13 in UCS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	MAP3K13 →	+1.257	+0.078	<.001	<.001	3	17
BLCA	HTRA3 →	-1.490	-0.047	<.001	<.001	3	16
SARC	CFD →	-1.842	-0.046	<.001	<.001	3	15
THYM	PFN1 →	-0.644	-0.034	<.001	<.001	3	15
COAD	SRGN →	-1.592	-0.066	<.001	<.001	3	15
UCS	ARPC1B →	-0.768	-0.061	.005	.005	1	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000172 vs MAP3K13 — UCS

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