Regulation of branching morphogenesis of a nerve

Across TCGA patient cohorts, RNA activity of the Regulation of branching morphogenesis of a nerve pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NFIA, RPL4, and RPS8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of branching morphogenesis of a nerve activity versus NFIA in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NFIA →	+0.498	+0.044	.001	.001	3	6
LUAD	RPL4 →	-0.296	-0.061	<.001	<.001	3	5
LUAD	RPS8 →	-0.229	-0.053	.002	.003	3	5
LUAD	RPL5 →	-0.181	-0.054	<.001	.002	3	5
LUAD	AGO1 →	+0.180	+0.055	.005	.001	2	6
CCRCC	PURA →	+0.216	+0.064	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000172 vs NFIA — BRCA

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