Regulation of branching morphogenesis of a nerve

Across TCGA patient cohorts, RNA activity of the Regulation of branching morphogenesis of a nerve pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNR1, PARM1, and PPP1R16B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of branching morphogenesis of a nerve activity versus CNR1 in LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CNR1 →	+1.007	+0.746	.001	.001	3	4
HNSC	PARM1 →	+0.926	+0.171	.001	.002	3	4
GBM	PPP1R16B →	+1.501	+0.674	<.001	<.001	3	4
GBM	PTGDS →	+1.466	+0.607	<.001	.003	3	4
GBM	CD22 →	+1.272	+0.795	<.001	.001	3	4
GBM	ATP8A1 →	+1.162	+0.601	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000172 vs CNR1 — LUAD

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