Regulation of DNA-templated transcription initiation

Across TCGA patient cohorts, RNA activity of the Regulation of DNA-templated transcription initiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC3, ZMYM3, and POGZ, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated transcription initiation activity versus SMC3 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC3 →	+0.293	+0.032	.001	.004	3	8
LSCC	ZMYM3 →	+0.321	+0.028	.002	.008	3	7
HNSC	POGZ →	+0.311	+0.072	<.001	<.001	3	7
LSCC	RPL26 →	-0.527	-0.041	<.001	<.001	3	6
LSCC	SIN3A →	+0.277	+0.034	<.001	.002	3	6
LSCC	SMC1A →	+0.287	+0.035	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000142 vs SMC3 — LSCC

Explore this scatter interactively →