Regulation of removal of superoxide radicals

Across TCGA cell cohorts, RNA activity of the Regulation of removal of superoxide radicals pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIAPH2, SASH1, and ZBTB18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DIAPH2 grouped by Regulation of removal of superoxide radicals-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DIAPH2 →	+1.515	+1.675	.002	.001	3	4
SOFT_TISSUE	SASH1 →	+2.394	+1.447	.001	.002	3	4
SKIN	ZBTB18 →	-0.570	-1.014	.003	<.001	3	4
BLOOD_Leukemia	H1-0 →	-3.698	-1.011	<.001	<.001	3	4
OESOPHAGUS	PSMF1 →	-1.108	-1.329	.001	<.001	3	4
KIDNEY	SLFN12 →	-1.328	-1.307	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DIAPH2 by Regulation of removal of superoxide radicals activity — SOFT_TISSUE

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