Regulation of sodium-dependent phosphate transport

Across TCGA patient cohorts, RNA activity of the Regulation of sodium-dependent phosphate transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OLFML1, OLFML3, and PLAC9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium-dependent phosphate transport activity versus OLFML1 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OLFML1 →	+0.992	+0.087	<.001	<.001	3	10
OV	OLFML3 →	+0.949	+0.086	<.001	<.001	3	10
UCEC	PLAC9 →	+1.084	+0.104	.001	<.001	3	10
BRCA	RPL5 →	-0.193	-0.061	<.001	<.001	3	9
LUAD	RRP1 →	-0.366	-0.107	<.001	<.001	3	9
COAD	RSU1 →	+0.498	+0.097	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000118 vs OLFML1 — OV

Explore this scatter interactively →