Regulation of sodium-dependent phosphate transport

Across TCGA cell cohorts, RNA activity of the Regulation of sodium-dependent phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANBP1, AAGAB, and SGPP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RANBP1 grouped by Regulation of sodium-dependent phosphate transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RANBP1 →	+0.894	+1.544	.005	.003	3	4
KIDNEY	AAGAB →	+0.513	+1.034	<.001	.001	3	4
KIDNEY	SGPP2 →	+2.226	+1.385	<.001	<.001	3	4
BLOOD_Lymphoma	ZNF445 →	-0.552	-1.636	.003	<.001	3	3
BREAST	BACE1 →	-1.006	-0.649	.001	.004	3	3
OVARY	PPP1R12A →	-0.843	-1.269	.007	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RANBP1 by Regulation of sodium-dependent phosphate transport activity — BONE

Explore this box plot interactively →