Regulation of macrophage apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC3A2, RPL22, and GPX8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC3A2 grouped by Regulation of macrophage apoptotic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SLC3A2 →	-0.958	-0.881	<.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	RPL22 →	-0.976	-1.419	<.001	.001	3	4
BLOOD_Myeloma	GPX8 →	-0.136	-1.810	.008	.002	2	4
BLOOD_Myeloma	ASB14 →	-0.309	-1.692	.002	.001	3	3
KIDNEY	ZSCAN5B →	-0.024	-0.903	.005	.007	3	3
BONE	DERL2 →	-0.787	-0.766	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC3A2 by Regulation of macrophage apoptotic process activity — BONE

Explore this box plot interactively →