Negative regulation of DNA-templated DNA replication

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA-templated DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZH2, MGP, and CHAF1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA-templated DNA replication activity versus EZH2 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EZH2 →	+0.907	+0.206	<.001	.003	2	7
COAD	MGP →	-1.315	-0.340	.005	.003	3	6
LSCC	CHAF1A →	+0.773	+0.935	<.001	<.001	3	6
COAD	PLN →	-1.611	-0.463	<.001	.002	3	6
BRCA	CCN5 →	-0.973	-0.247	<.001	.002	3	6
LSCC	ZNF887P →	+0.804	+0.876	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000104 vs EZH2 — BRCA

Explore this scatter interactively →