"Positive regulation of Wnt signaling pathway, planar cell polarity pathway"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf92, THAP6, and PLEKHH3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C2orf92 grouped by "Positive regulation of Wnt signaling pathway, planar cell polarity pathway"-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C2orf92 →	+1.236	+1.454	.006	.005	3	5
LUNG_NSCLC_LUAD	THAP6 →	+0.515	+0.885	.006	.001	3	4
LARGE_INTESTINE	PLEKHH3 →	+0.973	+0.687	.002	.006	3	4
LUNG_NSCLC_LUAD	PMP22 →	-2.307	-0.734	<.001	.004	3	4
LUNG_NSCLC_LUAD	NECTIN4 →	+1.606	+0.631	.002	.001	3	4
SKIN	GTF2B →	+0.401	+1.078	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C2orf92 by "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →