"Positive regulation of Wnt signaling pathway, planar cell polarity pathway"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERICH6B, NMBR, and ADGRE3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERICH6B grouped by "Positive regulation of Wnt signaling pathway, planar cell polarity pathway"-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ERICH6B →	-0.182	-0.113	<.001	.002	3	4
BREAST	NMBR →	-0.191	-0.907	.003	<.001	3	4
BREAST	ADGRE3 →	-0.190	-0.796	.004	.001	3	4
KIDNEY	ARID3A →	-0.231	-0.215	.005	<.001	2	4
SOFT_TISSUE	SNX19 →	+0.217	+0.367	<.001	<.001	3	3
BLOOD_Leukemia	CPA6 →	-0.218	-1.203	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERICH6B by "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" activity — SKIN

Explore this box plot interactively →