Regulation of type B pancreatic cell development

Across TCGA patient cohorts, RNA activity of the Regulation of type B pancreatic cell development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAFAH1B3, TAGLN2_S163, and PLS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of type B pancreatic cell development activity versus PAFAH1B3 in LUAD (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PAFAH1B3 →	+0.415	+0.053	<.001	<.001	3	6
PDAC	TAGLN2_S163 →	-0.594	-0.045	<.001	<.001	3	5
LUAD	PLS3 →	-0.523	-0.061	<.001	<.001	3	5
LSCC	RFX3_S155 →	+0.737	+0.067	<.001	<.001	3	5
PDAC	IRGQ →	+0.256	+0.052	.006	<.001	3	5
LUAD	CHAMP1 →	+0.193	+0.048	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000074 vs PAFAH1B3 — LUAD

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