Regulation of type B pancreatic cell development

Across TCGA patient cohorts, RNA activity of the Regulation of type B pancreatic cell development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRN2, SPTLC3, and BORCS6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of type B pancreatic cell development activity versus LRRN2 in OV (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LRRN2 →	-0.926	-0.188	.003	.001	3	4
LSCC	SPTLC3 →	+0.424	+0.192	.003	.009	3	3
LSCC	BORCS6 →	-0.244	-0.224	<.001	.002	3	3
LSCC	HSPD1P1 →	-0.299	-0.261	.003	.004	3	3
OV	TMEM199 →	-0.297	-0.201	.002	.001	3	3
HNSC	CFHR4 →	-0.958	-0.137	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000074 vs LRRN2 — OV

Explore this scatter interactively →