Regulation of type B pancreatic cell development

Across TCGA cell cohorts, RNA activity of the Regulation of type B pancreatic cell development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NANOS3, PPP6C, and MAP3K10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NANOS3 grouped by Regulation of type B pancreatic cell development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NANOS3 →	-0.477	-0.507	.001	.003	3	4
LUNG_NSCLC_LUAD	PPP6C →	-0.474	-0.452	.003	.005	2	5
LUNG_NSCLC_LUAD	MAP3K10 →	-0.534	-0.493	.009	.005	3	4
LUNG_NSCLC_LUSC	RBM43 →	-0.983	-1.314	.002	.002	3	4
BLOOD_Lymphoma	ZC3HAV1L →	+2.477	+1.789	<.001	<.001	3	3
LUNG_SCLC	MICAL1 →	-1.196	-0.868	.007	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NANOS3 by Regulation of type B pancreatic cell development activity — BREAST

Explore this box plot interactively →