Regulation of type B pancreatic cell development

Across TCGA cell cohorts, RNA activity of the Regulation of type B pancreatic cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHEB, CHPF2, and MTPN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of type B pancreatic cell development activity versus RHEB in LUNG_NSCLC_LUAD (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RHEB →	+0.770	+0.339	<.001	<.001	3	8
BREAST	CHPF2 →	+0.903	+0.727	.003	.008	3	7
OESOPHAGUS	MTPN →	+0.901	+0.268	<.001	<.001	3	6
BLOOD_Lymphoma	HPS5 →	+0.624	+0.162	.001	.009	2	6
LUNG_NSCLC_LUAD	COPS6 →	+0.761	+0.248	<.001	.002	3	5
BLOOD_Leukemia	CHCHD3 →	+0.636	+0.501	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000074 vs RHEB — LUNG_NSCLC_LUAD

Explore this scatter interactively →