Positive regulation of ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0E1, TGFBI, and AFAP1L1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin-dependent protein catabolic process activity versus ATP6V0E1 in LUNG_SCLC (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATP6V0E1 →	-0.989	-0.189	.003	.004	3	7
BONE	TGFBI →	-5.518	-0.236	<.001	.001	3	6
BONE	AFAP1L1 →	-2.606	-0.217	.002	<.001	3	6
BONE	CREB3 →	-1.527	-0.334	.003	<.001	3	5
BONE	LIF →	-3.291	-0.230	.001	.002	3	5
BONE	NCEH1 →	-2.144	-0.259	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000060 vs ATP6V0E1 — LUNG_SCLC

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