Negative regulation of ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFPL1S, C3orf80, and MAP1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin-dependent protein catabolic process activity versus RFPL1S in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFPL1S →	+0.578	+0.193	.001	<.001	3	5
CCRCC	C3orf80 →	+0.290	+0.142	<.001	.004	3	4
UCEC	MAP1A →	+0.920	+0.327	<.001	<.001	2	5
GBM	NXPE3 →	+0.694	+0.230	<.001	.001	3	4
PDAC	SIGLEC9 →	+0.414	+0.098	.001	.009	3	4
CCRCC	APLP1 →	+0.594	+0.196	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000059 vs RFPL1S — GBM

Explore this scatter interactively →