Regulation of ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIFK, FBXO41, and DCXR, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin-dependent protein catabolic process activity versus NIFK in BRCA (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NIFK →	+0.606	+0.206	.009	.003	3	2
BRCA	FBXO41 →	+2.300	+0.233	.007	.003	3	2
BRCA	DCXR →	+1.298	+0.206	.003	.003	3	2
BRCA	ZNHIT2 →	+1.903	+0.206	.005	.003	3	2
BRCA	B4GAT1 →	+2.743	+0.233	.007	.003	3	2
BRCA	KLHL41 →	+1.183	+0.233	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000058 vs NIFK — BRCA

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