Positive regulation of non-canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of non-canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSANTD3, CCDC57, and UBAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSANTD3 grouped by Positive regulation of non-canonical Wnt signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MSANTD3 →	-1.719	-1.739	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CCDC57 →	+0.812	+0.762	<.001	<.001	3	4
PANCREAS	UBAP2 →	-0.862	-1.319	<.001	<.001	3	3
URINARY_TRACT	SORL1 →	+4.776	+1.741	.001	<.001	3	3
URINARY_TRACT	MARCHF4 →	-3.118	-1.259	.003	.001	3	3
STOMACH	PPBP →	+0.295	+0.930	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSANTD3 by Positive regulation of non-canonical Wnt signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →