Positive regulation of non-canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of non-canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DKK1, BCL7A, and KCNJ11, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of non-canonical Wnt signaling pathway activity versus DKK1 in OVARY (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DKK1 →	+3.625	+0.195	<.001	<.001	3	11
BLOOD_Lymphoma	BCL7A →	-2.011	-0.115	.005	<.001	3	8
BONE	KCNJ11 →	-0.872	-0.189	.004	.001	3	8
BLOOD_Lymphoma	PELI1 →	-1.301	-0.114	.002	<.001	3	7
SOFT_TISSUE	HEYL →	-2.045	-0.125	<.001	.002	3	7
BONE	HSDL1 →	-1.016	-0.234	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000052 vs DKK1 — OVARY

Explore this scatter interactively →