Positive regulation of non-canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of non-canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSP90AA1, ATP5MPL, and SLC25A3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of non-canonical Wnt signaling pathway activity versus HSP90AA1 in KIDNEY (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HSP90AA1 →	+1.459	+1.891	.007	<.001	3	7
PANCREAS	ATP5MPL →	+0.750	+1.094	.001	.007	2	6
PANCREAS	SLC25A3 →	+1.120	+1.740	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	METAP2 →	+1.003	+1.298	<.001	.002	2	6
PANCREAS	MRPL42 →	+0.993	+1.329	.003	.001	2	5
STOMACH	SCLY →	+1.536	+1.785	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000052 vs HSP90AA1 — KIDNEY

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