Negative regulation of non-canonical Wnt signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of non-canonical Wnt signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SFRP2, TAGLN, and DPYSL3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of non-canonical Wnt signaling pathway activity versus SFRP2 in UCEC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SFRP2 →	+1.255	+0.115	<.001	<.001	3	9
OV	TAGLN →	+1.364	+0.144	<.001	<.001	3	9
OV	DPYSL3 →	+0.481	+0.083	<.001	<.001	3	9
OV	SERPINF1 →	+0.869	+0.088	<.001	<.001	3	8
HNSC	SFRP1 →	+0.927	+0.120	<.001	<.001	3	8
CCRCC	SFRP4 →	+1.062	+0.101	.005	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000051 vs SFRP2 — UCEC

Explore this scatter interactively →