Negative regulation of cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AFAP1L1, MCAM, and PROC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-cell adhesion mediated by cadherin activity versus AFAP1L1 in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AFAP1L1 →	+0.468	+0.086	.001	<.001	3	6
LUAD	MCAM →	+0.532	+0.079	<.001	<.001	3	6
CCRCC	PROC →	+0.375	+0.058	<.001	<.001	3	6
GBM	VWF →	+0.224	+0.056	.009	.001	3	6
BRCA	RFLNB →	+0.474	+0.061	<.001	<.001	3	5
GBM	VWA1 →	+0.422	+0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000048 vs AFAP1L1 — GBM

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