Negative regulation of cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFTN1, ANKRD37, and LINC00702, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-cell adhesion mediated by cadherin activity versus RFTN1 in LUAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFTN1 →	+0.527	+0.240	.001	.009	3	4
PDAC	ANKRD37 →	+0.511	+0.098	.007	.003	3	4
PDAC	LINC00702 →	+0.397	+0.113	.001	.006	3	4
CCRCC	LIMS2 →	+0.702	+0.262	<.001	.001	3	4
CCRCC	RGCC →	+0.982	+0.284	<.001	<.001	3	4
CCRCC	RECK →	+0.321	+0.245	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000048 vs RFTN1 — LUAD

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