Negative regulation of double-strand break repair via homologous recombination

Across TCGA patient cohorts, RNA activity of the Negative regulation of double-strand break repair via homologous recombination pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RRP36_S73, and SMC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of double-strand break repair via homologous recombination activity versus RFC2 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.398	+0.069	.001	<.001	3	10
LSCC	RRP36_S73 →	+0.795	+0.052	<.001	.001	3	10
LUAD	SMC2 →	+0.710	+0.100	<.001	<.001	3	10
LUAD	SMC4 →	+0.676	+0.100	<.001	<.001	3	10
LUAD	CDK1 →	+0.941	+0.096	<.001	<.001	3	10
LUAD	ECT2_T359 →	+1.534	+0.095	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000042 vs RFC2 — LSCC

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