Regulation of animal organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of animal organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF1, SSPN, and EZH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of animal organ morphogenesis activity versus FGF1 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGF1 →	+0.973	+0.709	<.001	<.001	3	5
BRCA	SSPN →	+0.788	+0.511	<.001	<.001	3	5
BRCA	EZH2 →	-0.712	-0.481	<.001	.001	3	5
BRCA	PRICKLE2 →	+0.878	+0.606	<.001	<.001	3	5
BRCA	OIP5 →	-0.536	-0.537	.002	.004	3	4
LUAD	MRPL27 →	-0.252	-0.293	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000027 vs FGF1 — BRCA

Explore this scatter interactively →