Regulation of animal organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of animal organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFF3, LDLRAD2, and NOL9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AFF3 grouped by Regulation of animal organ morphogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AFF3 →	-2.667	-1.571	.003	.007	3	5
STOMACH	LDLRAD2 →	-0.976	-0.336	<.001	.002	3	4
LARGE_INTESTINE	NOL9 →	+0.752	+0.722	<.001	.001	3	4
BONE	PRICKLE1 →	-1.998	-1.050	.006	.006	3	4
BONE	GRN →	-1.213	-1.010	.003	.009	3	4
BONE	CADPS2 →	+3.667	+1.625	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AFF3 by Regulation of animal organ morphogenesis activity — BONE

Explore this box plot interactively →