Regulation of animal organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of animal organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACSTD2, STX2, and LIX1L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of animal organ morphogenesis activity versus TACSTD2 in URINARY_TRACT (Pearson r = 0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TACSTD2 →	+6.440	+2.387	<.001	<.001	3	8
LUNG_NSCLC_LUAD	STX2 →	-1.209	-1.111	.004	.003	2	8
URINARY_TRACT	LIX1L →	-2.531	-1.812	<.001	.005	2	8
LUNG_NSCLC_LUSC	CDH3 →	+6.017	+2.381	<.001	<.001	3	7
OVARY	EPHA1 →	+2.851	+1.546	.001	<.001	3	7
OVARY	OVOL2 →	+3.350	+1.686	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000027 vs TACSTD2 — URINARY_TRACT

Explore this scatter interactively →