Regulation of male gonad development

Across TCGA patient cohorts, RNA activity of the Regulation of male gonad development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX9, MAP1B_S614, and WNT4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of male gonad development activity versus SOX9 in LSCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOX9 →	+0.705	+0.104	<.001	<.001	3	5
HNSC	MAP1B_S614 →	-0.516	-0.051	.005	.005	3	5
PDAC	WNT4 →	+0.774	+0.059	.001	.003	3	4
PDAC	DDX3Y →	-1.160	-0.056	.001	<.001	3	4
LUAD	RCC1 →	+0.414	+0.081	<.001	<.001	3	4
BRCA	TARBP2_S152 →	-0.358	-0.057	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000018 vs SOX9 — LSCC

Explore this scatter interactively →