Negative regulation of protein localization to cell surface

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRD-AS1, DPT, and ADAR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to cell surface activity versus PTPRD-AS1 in COAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTPRD-AS1 →	+0.716	+0.174	<.001	<.001	3	3
HNSC	DPT →	+1.241	+0.788	.001	.001	3	3
LSCC	ADAR →	-0.360	-0.091	<.001	.006	3	2
LSCC	SLAMF9 →	+0.871	+0.107	<.001	.005	3	2
LSCC	NPNT →	+0.760	+0.112	.009	.006	3	2
LSCC	SCUBE2 →	+0.547	+0.090	.007	.008	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000009 vs PTPRD-AS1 — COAD

Explore this scatter interactively →