Regulation of protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHM1, SFXN3, and RAB11FIP5, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell surface activity versus PLEKHM1 in BONE (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PLEKHM1 →	+1.097	+0.151	<.001	.002	3	12
SOFT_TISSUE	SFXN3 →	+2.584	+0.129	<.001	<.001	3	12
BONE	RAB11FIP5 →	+1.756	+0.174	<.001	<.001	3	12
BONE	TOM1 →	+0.992	+0.109	<.001	<.001	3	11
BONE	MAN2B2 →	+1.256	+0.106	<.001	<.001	3	11
BONE	MVP →	+2.825	+0.121	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000008 vs PLEKHM1 — BONE

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