Xenobiotic transport across blood-brain barrier

Across TCGA patient cohorts, RNA activity of the Xenobiotic transport across blood-brain barrier pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC52A3, AMACR, and RNA5SP464, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transport across blood-brain barrier activity versus SLC52A3 in COAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC52A3 →	+0.872	+0.829	<.001	.002	3	3
COAD	AMACR →	+0.674	+0.717	.002	.004	3	3
GBM	RNA5SP464 →	-0.675	-0.615	.005	.003	3	3
COAD	CEBPA-DT →	+0.853	+1.132	<.001	<.001	3	3
GBM	NEBL →	+1.002	+0.615	<.001	.004	3	3
COAD	FGF20 →	+1.874	+0.925	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990962 vs SLC52A3 — COAD

Explore this scatter interactively →