Xenobiotic transport across blood-brain barrier

Across TCGA cell cohorts, RNA activity of the Xenobiotic transport across blood-brain barrier pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF41, CTU1, and LRFN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF41 grouped by Xenobiotic transport across blood-brain barrier-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZNF41 →	-0.211	-0.395	.001	.002	3	5
OESOPHAGUS	CTU1 →	-0.138	-0.308	.006	.006	3	3
LUNG_NSCLC_LUSC	LRFN5 →	+0.267	+0.655	.007	<.001	3	3
KIDNEY	FGF7 →	-0.151	-0.200	.006	<.001	3	3
LUNG_SCLC	NUP98 →	+0.373	+0.225	<.001	<.001	3	3
SOFT_TISSUE	CCDC34 →	-0.341	-0.418	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF41 by Xenobiotic transport across blood-brain barrier activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →