Double-strand break repair involved in meiotic recombination

Across TCGA patient cohorts, RNA activity of the Double-strand break repair involved in meiotic recombination pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and UNG_T60, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair involved in meiotic recombination activity versus SMC2 in OV (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMC2 →	+0.653	+0.072	<.001	<.001	3	10
GBM	SMC4 →	+0.652	+0.572	<.001	<.001	3	10
OV	UNG_T60 →	+1.039	+0.096	<.001	<.001	3	10
OV	CDC20_T70 →	+1.093	+0.072	<.001	.001	3	10
OV	FEN1 →	+0.600	+0.084	<.001	<.001	3	10
OV	KPNA2 →	+0.748	+0.090	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990918 vs SMC2 — OV

Explore this scatter interactively →