Adaptive thermogenesis

Across TCGA patient cohorts, RNA activity of the Adaptive thermogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCL2, CYGB, and PECAM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adaptive thermogenesis activity versus PLCL2 in UCEC (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLCL2 →	+0.268	+0.033	.001	.001	3	7
COAD	CYGB →	+0.216	+0.013	<.001	.002	3	7
GBM	PECAM1 →	+0.342	+0.036	<.001	.002	3	7
GBM	RPP40 →	-0.287	-0.035	<.001	<.001	3	6
HNSC	SPTBN1_S257 →	+0.550	+0.048	<.001	<.001	3	6
HNSC	HAAO →	+0.496	+0.043	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990845 vs PLCL2 — UCEC

Explore this scatter interactively →