Response to lectin

Across TCGA patient cohorts, RNA activity of the Response to lectin pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP7, LRP1, and PRKG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to lectin activity versus FKBP7 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FKBP7 →	+0.376	+0.049	.003	.004	3	7
BRCA	LRP1 →	+0.416	+0.042	<.001	<.001	3	7
BRCA	PRKG1 →	+0.546	+0.067	<.001	<.001	3	7
COAD	CD8A →	-0.693	-0.057	<.001	.006	3	7
COAD	PSME2 →	-0.378	-0.060	.001	<.001	3	7
COAD	TAP1 →	-0.410	-0.047	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990840 vs FKBP7 — LSCC

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