Ligand-gated ion channel signaling pathway

Across TCGA patient cohorts, RNA activity of the Ligand-gated ion channel signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNN3, TLN1_T1263, and FLNA_S2128, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ligand-gated ion channel signaling pathway activity versus CNN3 in BRCA (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNN3 →	-0.492	-0.051	<.001	<.001	3	7
OV	TLN1_T1263 →	-0.608	-0.049	.004	<.001	3	6
OV	FLNA_S2128 →	-0.978	-0.054	<.001	<.001	3	6
BRCA	TPM4 →	-0.446	-0.036	<.001	<.001	3	6
COAD	CLEC3B →	-0.596	-0.046	<.001	<.001	3	6
LSCC	AKAP12_S612 →	-0.824	-0.059	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990806 vs CNN3 — BRCA

Explore this scatter interactively →