Ligand-gated ion channel signaling pathway

Across TCGA patient cohorts, RNA activity of the Ligand-gated ion channel signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS18, DBF4, and CTSG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ligand-gated ion channel signaling pathway activity versus RPS18 in GBM (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPS18 →	-0.279	-0.739	<.001	<.001	3	5
LUAD	DBF4 →	-0.548	-0.170	.001	.009	3	4
LSCC	CTSG →	+0.805	+0.186	<.001	.002	3	4
LUAD	FBXO5 →	-0.486	-0.183	.002	.002	3	4
LUAD	RIOK1 →	-0.390	-0.192	.001	<.001	3	4
LUAD	HDC →	+0.803	+0.186	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990806 vs RPS18 — GBM

Explore this scatter interactively →