Ligand-gated ion channel signaling pathway

Across TCGA cell cohorts, RNA activity of the Ligand-gated ion channel signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX10, RAB8A, and CPD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX10 grouped by Ligand-gated ion channel signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SNX10 →	-1.545	-1.071	.001	<.001	3	5
BLOOD_Myeloma	RAB8A →	-0.912	-1.645	.006	<.001	2	5
SKIN	CPD →	-0.895	-1.058	.003	<.001	3	4
SKIN	NDRG1 →	-2.998	-0.998	.001	.003	3	4
OVARY	NBR1 →	-0.619	-0.981	.003	.001	3	4
OESOPHAGUS	SNAI3 →	-0.478	-1.170	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX10 by Ligand-gated ion channel signaling pathway activity — SKIN

Explore this box plot interactively →