Ligand-gated ion channel signaling pathway

Across TCGA cell cohorts, RNA activity of the Ligand-gated ion channel signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF3B, ASB3, and ZBTB49, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ligand-gated ion channel signaling pathway activity versus KIF3B in PANCREAS (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KIF3B →	-0.988	-0.349	.002	<.001	3	3
SKIN	ASB3 →	-0.472	-1.429	.002	<.001	3	3
BREAST	ZBTB49 →	-0.553	-0.298	.003	.007	3	3
OESOPHAGUS	AKAP10 →	-1.343	-0.610	<.001	<.001	3	3
OESOPHAGUS	ASIC1 →	-1.426	-0.504	.002	<.001	3	3
OESOPHAGUS	INPP5J →	-1.519	-0.504	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990806 vs KIF3B — PANCREAS

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