Dorsal root ganglion development

Across TCGA cell cohorts, RNA activity of the Dorsal root ganglion development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALY, TMIGD2, and TUBB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal root ganglion development activity versus RALY in LUNG_SCLC (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RALY →	+0.632	+0.300	<.001	<.001	3	3
LUNG_SCLC	TMIGD2 →	+0.525	+0.328	.008	.001	3	3
LUNG_SCLC	TUBB3 →	+2.513	+0.337	.001	.002	3	3
LIVER	SEC24B →	+0.504	+0.357	<.001	.001	3	3
LIVER	PBXIP1 →	+1.773	+0.471	<.001	.004	2	4
BLOOD_Lymphoma	IL12A →	-1.562	-0.619	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990791 vs RALY — LUNG_SCLC

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