Presynaptic active zone organization

Across TCGA patient cohorts, RNA activity of the Presynaptic active zone organization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TESMIN, BLM, and GPR68, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynaptic active zone organization activity versus TESMIN in HNSC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TESMIN →	-1.001	-0.674	<.001	<.001	3	4
UCEC	BLM →	-0.658	-0.578	<.001	.002	3	4
LUAD	GPR68 →	+0.651	+0.372	<.001	<.001	3	4
LUAD	CDKL2 →	+0.961	+0.365	.001	<.001	3	4
LSCC	SNORD82 →	-0.785	-0.607	<.001	<.001	3	4
GBM	VSTM2L →	+1.376	+1.207	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990709 vs TESMIN — HNSC

Explore this scatter interactively →